Which condition is not typically a part of acquired thrombophilia?

• A. Hyperhomocystenemia
• B. Factor V Leiden
• C. Lupus
• D. Antiphospholipid syndrome

Answer: (B)

Factor V Leiden is a hereditary genetic mutation that causes an increased risk of venous thromboembolism. It is not considered an acquired condition but rather a congenital or inherited one. Acquired thrombophilia refers to conditions that arise due to environmental factors or illnesses that increase the risk of clotting, rather than those that are present at birth.

The other conditions listed are associated with acquired thrombophilia. Hyperhomocystinemia can result from nutritional deficiencies, certain medications, or other acquired factors leading to an increased risk of thrombosis. Lupus, specifically lupus anticoagulant, is an autoimmune condition that can result in an increased tendency to form blood clots. Antiphospholipid syndrome is another acquired disorder characterized by the presence of antiphospholipid antibodies, which contribute to increased clotting risk. These conditions arise in response to factors other than genetic predisposition, aligning them with the concept of acquired thrombophilia.